Many vape mods are designed for sub-ohm vaping, so they are usually used with an e-liquid that has higher vegetable glycerin (VG) content. Often used in lower nicotine strength, high-VG juice is generally thicker than high-PG e-juice and produces fuller vape clouds.

Pod mods, on the other hand, are best used with nicotine salt e-liquid. This juice has a higher concentration of nicotine and is available in higher nicotine strengths. It is highly advised not to use nic salts with a sub-ohm vape mod.